Methods of making a molecular detection chip having a metal...

Details Methods of making a molecular detection chip having a metal... Methods of making a molecular detection chip having a metal...

2011-01-04

2011-01-04

Garber, Charles D (Department: 2812)

Semiconductor device manufacturing: process

Making field effect device having pair of active regions...

Having insulated gate

C435S174000, C435S283100, C435S287200, C422S068100, C422S082010, C257SE21051, C438S289000

Reexamination Certificate

active

07863140

ABSTRACT:
A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection chip are provided. A molecular detection method, particularly, qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided. The formation of the MOSFET on the sidewalls of the micro-fluid channel makes easier to highly integrate a molecular detection chip. In addition, immobilization of probes directly on the surface of a gate electrode ensures the molecular detection chip to check for the immobilization of probes and coupling of a target molecule to the probes in situ.

REFERENCES:
patent: 4238757 (1980-12-01), Schenck
patent: 4325181 (1982-04-01), Yoder
patent: 4460910 (1984-07-01), Chappell et al.
patent: 4478222 (1984-10-01), Koning et al.
patent: 4657658 (1987-04-01), Sibbald
patent: 4764797 (1988-08-01), Shaw et al.
patent: 4777019 (1988-10-01), Dandekar
patent: 4874499 (1989-10-01), Smith et al.
patent: 4877582 (1989-10-01), Oda et al.
patent: 5078855 (1992-01-01), Mochizuki et al.
patent: 5272913 (1993-12-01), Toda et al.
patent: 5396089 (1995-03-01), Wieck et al.
patent: 5466348 (1995-11-01), Holm-Kennedy
patent: 5589688 (1996-12-01), Kimura et al.
patent: 5662768 (1997-09-01), Rostoker
patent: 5701017 (1997-12-01), Patel et al.
patent: 5827482 (1998-10-01), Shieh et al.
patent: 5892252 (1999-04-01), Hammond et al.
patent: 5995209 (1999-11-01), Ohman et al.
patent: 6060327 (2000-05-01), Keen
patent: 6085576 (2000-07-01), Sunshine et al.
patent: 6093612 (2000-07-01), Suh
patent: 6144447 (2000-11-01), Ohman et al.
patent: 6171850 (2001-01-01), Nagle et al.
patent: 6212956 (2001-04-01), Donald et al.
patent: 6287776 (2001-09-01), Hefti
patent: 6482639 (2002-11-01), Snow et al.
patent: 6534379 (2003-03-01), Fisher et al.
patent: 6537437 (2003-03-01), Galambos et al.
patent: 6766817 (2004-07-01), da Silva
patent: 6918404 (2005-07-01), da Silva
patent: 7066586 (2006-06-01), da Silva
patent: 7781167 (2010-08-01), Lim et al.
patent: 2002/0127736 (2002-09-01), Chou et al.
patent: 2002/0177135 (2002-11-01), Doung et al.
patent: 2003/0036054 (2003-02-01), Ladisch et al.
patent: 2005/0170347 (2005-08-01), Miyahara et al.
patent: 1205079 (1999-01-01), None
patent: 44 42 685 (1996-03-01), None
patent: 0 633 468 (1995-01-01), None
patent: 0 740 151 (1996-10-01), None
patent: 2 236 903 (1991-04-01), None
patent: 53-146693 (1978-12-01), None
patent: 58-184540 (1983-10-01), None
patent: 59-178353 (1984-10-01), None
patent: 62-263460 (1987-11-01), None
patent: 1-107144 (1989-04-01), None
patent: 10-80266 (1998-03-01), None
patent: 11-505606 (1999-05-01), None
patent: 8602669 (1988-05-01), None
patent: WO 93/08464 (1993-04-01), None
patent: WO 99/41606 (1999-08-01), None
patent: WO 99/44046 (1999-09-01), None
patent: WO 99/50643 (1999-10-01), None
patent: WO 00/75276 (2000-12-01), None
patent: WO 01/13432 (2001-02-01), None
Böhm et al. “A flow-through cell with integrated coulometric pH actuator”Sensors and Actuators B, 47(1-3):48-53 (1998).
International Search Report, PCT/KR02/00746, Apr. 23, 2002.
Lauwers et al. “A CMOS Multi-Parameter Biochemical Microsensor with Temperature Control and Signal Interfacing”Digest of Technical Papers—2001 IEEE International Solid-State Circuits Conference, pp. 244-245+452 (2001).
Perkins et al. “An Active Microelectronic Transducer for Enabling Label-Free Miniaturized Chemical Sensors”Technical Digest—2000 IEDM International Electron Devices Meeting, pp. 407-410 (2000).
Sakurai et al. “Real-Time Monitoring of DNA Polymerase Reactions by a Micro ISFET pH Sensor”Anal. Chem. 64:1996-1997 (1992).
Supplementary European Search Report, EP 02 72 0663, Nov. 2, 2006.
Tsuruta et al. “Detection of the products of polymerase chain reaction by an ELISA system based on an ion sensitive field effect transistor”Journal of Immunological Methods176:45-52 (1994.
Tsuruta et al. “Quantitation of IL-1β mRNA by a combined method of RT-PCT and an ELISA based on ion-sensitive field effect transistor”Journal of Immunological Methods180:259-264 (1995).
Van Steenkist et al. “A microsensor array of biochemical sensing”Sensors and Actuators B44:409-412 (1997).

Affiliated with

Also associated with

Rating

Methods of making a molecular detection chip having a metal... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of making a molecular detection chip having a metal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of making a molecular detection chip having a metal... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2659667