Plant protecting and regulating compositions – Plant growth regulating compositions – Organic active compound containing
Reexamination Certificate
2000-12-11
2002-03-05
Pryor, Alton (Department: 1616)
Plant protecting and regulating compositions
Plant growth regulating compositions
Organic active compound containing
C504S130000, C504S140000, C514S224500, C514S460000, C514S635000
Reexamination Certificate
active
06352960
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a controlling agent for agricultural or horticultural bacterial disease comprising bis(8-guanidinooctyl)amine or salts thereof as an active ingredient, to a controlling agent for agricultural or horticultural bacterial disease obtained by adding to the controlling agent, other active ingredient of a controlling agent for agricultural or horticultural bacterial disease than bis(8-guanidinooctyl)amine or salts thereof, and to a method for controlling bacterial diseases in the field of agriculture and horticulture using them.
BACKGROUND ART
Bacterial plant diseases are known to be diseases difficult to control, and inorganic copper agents, organic copper agents, streptomycin agents, oxolinic acid, etc. are used as controlling agent therefor. However, sufficient controlling effects cannot always be obtained depending on the crop. Some combinations of agents and crops may be impossible to use due to phytotoxicity. Therefore, development of controlling agents having a novel effect is keenly desired.
There has been found no drug having controlling effects on both plant diseases caused by fungi (filamentous fungi) and bacterial plant diseases except copper agents. To control both of them simultaneously, it has been necessary to use a plurality of different components in admixture.
Bis(8-guanidinooctyl)amine has another name of Iminoctadine. Salts thereof, Iminoctadine acetic acid salt and Iminoctadine arbesylic acid salt (hereinafter, abbreviated as “Iminoctadine ABS salt”) have broad anti filmentaus fungi spectra and are utilized as controlling agent for agricultural or horticultural disease not only in our country but also overseas. However, for bacterial diseases, the effect of these compounds has not been known presumably due to the fact that they exhibit almost no antibacterial activity in vitro. Consequently no case has been known at all in which they are used as controlling agent for bacterial plant disease.
The first patent application in reference to Iminoctadine is Japanese Patent Publication (Kokoku) No. Sho 43-27335, which discloses that guanidino derivatives including Iminoctadine are also effective against pathogenic bacteria. However, though it is described that, in the test example, bis (10-guanidinodecyl) amine sulfate and bis (12-guanidinododecyl) amine hydrochloride revealed to have in vitro antibacterial activity against plant pathogenic bacteria such as the genus Xanthomonas and the genus Pseudomonas but bis (8-guanidiooctyl) amine sulfate has no activity thereagainst.
Later on, many related patent applications (Japanese Patent Laid-open (Kokai) No. Sho 50-105906, Japanese Patent Laid-open (Kokai) No. Sho 56-95102, Japanese Patent Laid-open (Kokai) No. Sho 57-48902, Japanese Patent Publication (Kokoku) No. Sho 57-61252, Japanese Patent Publication (Kokoku) No. Sho 57-7605, Japanese Patent Publication (Kokoku) No. Hei 2-4569, Japanese Patent Publication (Kokoku) No. Hei 7-5537, Japanese Patent Laid-open (Kokai) No. Hei 6-234608) have been filed. However, no mention has been made of therein that Iminoctadine and salts thereof are effective in controlling bacterial plant diseases.
In Japan, Iminoctadine acetic acid salt and Iminoctadine ABS salt have not been recorded in agricultural chemicals register as controlling agent for bacterial plant disease. There is no description that the aforementioned agents have controlling effects on bacterial plant diseases, in technical informations or literature on the agent. Compounds such as Guazatine, Befran (Iminoctadine acetic acid salt) and Bellkute (Iminoctadine ABS salt) were described in Farm Chemicals Handbook (1997) and Guazatine and Iminoctadine were described in Pesticide Manual (1997 p.651-653, p.709-710). However, in neither case there is a description that these compounds are effective against bacteria.
As a reason that it is difficult to develop controlling agents for bacterial plant disease, it is well known that there are many cases where substances which exhibit extremely high antibacterial activity in vitro cannot be expected to exhibit sufficient effects in the field. Conversely, no agent has been known that has no activity in vitro but exhibits high effect in vivo.
As for the agents currently used as controlling agent for bacterial plant disease, few controlling agents exhibit sufficient effects due to insufficiency of absorption and transition or residual activity so is that bacterial plant diseases have been regarded as the difficult-to-control diseases. Use of mixed preparations and in situ mixing and spreading by cultivators have taken place frequently and stronger controlling agents are desired.
To decrease the incidence of drug resistant bacteria and prevent the proliferation of drug resistant bacteria, development of novel controlling agent for bacterial plant disease, which has different effect, is keenly desired.
That is, it has been known that copper preparations have sterilization effect due to release of copper ions, oxolinic acid causes inhibition of replication of DNA, and streptomycin agents cause translation error and coupling inhibition of mRNA, and development of agents which show difference in effect from any of them has been desired.
SUMMARY OF THE INVENTION
The present inventors made extensive research on agents which have less phytotoxicity and which are effective against bacterial plant diseases known as difficult-to-control diseases and, as a result, have found that Iminoctadine and salts thereof exhibit considerable controlling effects on bacterial plant diseases, thus achieving the present invention.
Further, the present inventors have found that the addition of inorganic copper agents, organic copper agents, streptomycin agents, oxolinic acid, kasugamycin or the like, which have been used as controlling agent for agricultural or horticultural bacterial disease in the past, to Iminoctadine increases the controlling effects, thus achieving the present invention.
In addition, since the mixed agent contains Iminoctadine having a new effect, it is expected that the mixed agent will defer and suppress emergence of drug resistant bacteria.
The present inventors have made extensive research with a view to solving these problems and have conducted field tests using Iminoctadine or salts thereof, which have hitherto been known to be effective against filamentous fungi but have not been known as controlling agent for bacterial disease, solely or in combination with other active ingredient of a controlling agent for agricultural or horticultural bacterial disease than Iminoctadine. As a result, the present inventors have found, surprisingly, that Iminoctadine alone exhibited high controlling effect, and that mixed agent containing Iminoctadine and the other active ingredient of controlling agent for agricultural or horticultural bacterial disease than Iminoctadine exhibited extremely high controlling effect due to synergistic effect.
That is, the present invention relates to a controlling agent for agricultural or horticultural bacterial disease containing Iminoctadine or salt thereof.
The present invention also relates to a mixed agent containing the above controlling agent and the other active ingredient of controlling agent for agricultural or horticultural bacterial disease than Iminoctadine or salt thereof.
The present invention further relates to a method for controlling bacterial diseases in the field of agriculture and horticulture, which comprises the step of applying the controlling agent for agricultural or horticultural bacterial disease containing Iminoctadine or salt thereof, or a mixed agent prepared by adding the other active ingredient of controlling agent for agricultural or horticultural bacterial disease than Iminoctadine or salt thereof to the controlling agent, to a crop or to a field.
In this specification,
“Controlling agent for agricultural or horticultural disease” refers to a agent which suppress proliferation of pathogenic microbe that have infected agricultural or horticultural crops and which control various damages
Tanino Shigeki
Teraoka Takeshi
Armstrong Westerman & Hattori, LLP
Meiji Seika Kaisha Ltd.
Pryor Alton
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