Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-06
1997-10-07
Feisee, Lila
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435328, 435330, 4353201, 5303873, 5303877, 5303885, C07H 2104, C12N 1563, A61K 39395
Patent
active
056749945
ABSTRACT:
The invention relates to polynucleotides encoding the BW 835 variable domain of an antibody against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), and expression vectors containing the polynucleotides.
REFERENCES:
Birggs et al 1993. Eur. J. Cancer vol. 29(A) (2):230-237.
Paul, WE 1993 Fundamental Immunology: 242.
Vrana et al 1978 Proc Natl Acad Sci vol. 75(4):1957-1961.
Hang et al 1992 Gene 121:331-335.
Buchegger et al., "Monoclonal Antibodies Identify a CEA Crossreacting Antigen of 95 kD (NCA-95) Distinct in Antigenicity and Tissue Distribution From the Previously Described NCA of 55 kD", Int. J. Cancer, 33:643-649, (1984).
Bosslet et al., "Quantitative considerations supporting the irrelevance of of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas", Eur. J. Nucl. Med., 14:523-528 (1988).
Shimizu et al., "Isolation and Characterization of Mucin-Like Glycoprotein in Human Milk Fat Globule Membrane", J. Biochem., 91:515-524 (1982).
Girling et al., "A Core Protein Epitope of the Polymorphic Eipthelial Mucin Detected by the Monoclonal Antibody SM-3 is Selectively Exposed in a Range of Primary Carcinomas", Int. J. Cancer, 43:1072-1067 (1989).
Taylor-Papadimitriou et al., "Monoclonal Antibodies to Epithelium-Specific Components of the Human Milk Fat Globule Membrane: Production and Reaction With Cells in Culture", Int. J. Cancer, 28:17-21 (1981).
Gosling, "A Decade of Development in Immunoassay Methodology", Clin. Chem., 36(8):1408-1427 (1990).
Cordell et al., "Immunoenzymatic Labeling of Monoclonal Antibodies Using Immune Complexes of Alkaline Phosphatase and Monoclonal Anti-alkaline Phosphatase (APAAP Complexes)", Journal of Histochemistry and Cytochemistry, 32(2):219-229 (1984).
Orlandi et al., "Cloning immunoglobulin variable domains for expression by the polymerase chain reaction", Proc.Natl.Acad.Sci. USA, 86:3833-3837(1989).
Sanger et al., "DNA sequencing with chain-terminating inhibitors", Proc. Natl. Acad. Sci. USA, 74(12):5463-5467 (1977).
Miller et al., "Monoclonal Antibody Therapeutic Trials in Seven Patients with T-Cell Lymphoma", Blood, 62(5):988-995 (1983).
Joseph et al., "In vivo labelling of granulocytes with .sup.99m Tc anti-NCA monoclonal anti-bodies for imaging inflammation", Eur. J. Nucl. Med., 14:367-373 (1988).
Jones et al., "Replacing the complementarity-determining regions in a human antibody with those from a mouse", Nature, 321:522-525 (1986).
Reichmann et al., "Reshaping human antibodies for therapy", Nature, 332:323-327 (1988).
Verhoeyen et al., "Reshaping Human Antibodies: Grafting an Antilysozyme Activity", Science, 239:1534-1536 (1988).
Kabat et al., "Sequence of Proteins of Immunological Interest", 4th Ed., US Department of Health and Human Services, US Government Printing Office (1987).
Sambrook, Fritsch, Maniatis, "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Laboratory, pp. 11-44, 51-127, 133-134, 141, 146, 150-167, 170, 188-193, 197-199, 248-255, 270-294, 310-328, 364-401, 438-506 (1982).
Sambrook Fritsch, Maniatis, "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Press, pp. 16.20-16.22, 16.30-16.40, 16.54-16.55 (1989).
Wirth et al., "Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure", Gene 73: 419-426 (1988).
Hieter et al., "Evolution of Human Immunoglobulin k J Region Genes*", The Journal of Biological Chemistry, 257(3): 1516-1522 (1982).
Gussow et al., "Humanization of Monoclonal Antibodies", Methods in Enzymology, 203:99-121 (1991).
Saragovi et al., "Design and Synthesis of a Mimetic from an Antibody Complementarity-Determining Region", Science, 253:792-795 (1991).
Tijssen, "The immobilization of immunoreactants on solid phases", Practice & Theory of Enzyme Immunoassays, pp. 297-328, (1984).
Kufe et al., "Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors", Hybridoma, 3(3): 223-232, (1984).
Burchell, et al., Cancer Research, vol. 47, pp. 5476-7482, Oct. 15, 1987.
Bosslet Klaus
Pfleiderer Peter
Seemann Gerhard
Behringwerke Aktiengesellschaft
Feisee Lila
Reeves Julie E.
LandOfFree
Polynucleotides encoding the anti-PEM antibody BW835 variable do does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotides encoding the anti-PEM antibody BW835 variable do, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding the anti-PEM antibody BW835 variable do will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2358320