Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-09-04
1989-07-25
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514242, 514245, 514253, 514269, 514272, 514274, 514275, 514318, 514323, 514333, 514339, 514361, 514362, 514363, 514364, 514365, 514369, 514370, 514372, 514374, 514376, 514377, 514378, 514380, 514381, 514383, 514384, 514385, 514386, 514389, 514390, 514391, 514392, 514397, 514403, 514404, 514406, 514407, 514414, 514415, 514419, 514254, 5142282, 5142292, 5142352, 540596, 540598, 540601, 540602, 540603, 544 3, 544 8, 544 582, 544 54, 544 55, 544 56, 544 63, 544 68, 544 88, 544 98, 544120, 544123, 544131, 5441
Patent
active
048514063
ABSTRACT:
The present invention provides indole derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl or aryl radical, R.sub.2 is a hydrogen atom or an alkyl, trihalogenomethyl, hydroxyl, cycloalkyl, cyano, carboxyl, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical; R.sub.2 is a heterocyclic five-membered ring containing 1 to 4 heteroatoms or a heterocyclic six-membered ring containing 1 to 5 heteroatoms, the heteroatoms of the five- and six-membered rings being the same or different and being nitrogen, oxygen or sulphur and one or more of the nitrogen atoms optionally carrying an oxygen atom, the said five- and six-membered rings optionally being substituted by one or more alkyl, alkoxy, alkylthio, oxo, hydroxyl, nitro, amino, halogen or cyano groups; or R.sub.2 is ##STR2## the tautomers thereof and the physiologically acceptable salts thereof with inorganic and organic acids.
The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
Furthermore, the present invention provides intermediates of the general formula: ##STR3## in which R.sub.1, R.sub.2, A and X have the same meanings as above, and processes for the preparation of these intermediates.
REFERENCES:
patent: 3322786 (1967-05-01), Sletzinger
patent: 4126620 (1978-11-01), Bell et al.
patent: 4144338 (1979-03-01), Bolhofer
patent: 4148895 (1979-04-01), Luttrell
patent: 4181665 (1980-01-01), McCall
patent: 4258185 (1981-03-01), Nakao
patent: 4479962 (1984-10-01), Wiedemann
patent: 4499181 (1985-02-01), Watanabe
Merck, Chem. Abs., 65, 20103(b), 1966.
Wentrup et al., "Synthesis of l-Azaazulene and Benz[a]azulene by Carbene . . . ", J. Am. Chem. Soc., 106, 3705-6, (1984).
Mullock et al., "Synthetic Uses of Polyphosphoric Acid and Its Ethyl . . . ", J. Chem. Soc., (c) 1970, 829-33.
Abstract: Japanese Patent Publication 58-8016(A), pub. 18 Jan. 1983.
Friebe Walter-Gunar
Mertens Alfred
Muller-Beckmann Bernd
Sponer Gisbert
Von Der Saal Wolfgang
Berch Mark L.
Boehringer Mannheim GmbH
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