Zinc finger protein derivatives and methods of using same

Details Zinc finger protein derivatives and methods of using same Zinc finger protein derivatives and methods of using same

2004-05-11

2011-12-06

Long, Scott (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C424S614000, C514S015800, C514S012200, C514S002600

Reexamination Certificate

active

08071285

ABSTRACT:
The present invention provides zinc finger nucleotide binding polypeptide variants that have at least three zinc finger modules that bind to a target cellular nucleotide sequence and modulate the transcriptional function of the cellular nucleotide sequence.

REFERENCES:
patent: 6140081 (2000-10-01), Barbas
patent: 6140466 (2000-10-01), Barbas, III et al.
patent: 6242568 (2001-06-01), Barbas, III et al.
patent: 6534261 (2003-03-01), Cox et al.
patent: 2002/0076393 (2002-06-01), Fehlbaum et al.
patent: 2003/0037355 (2003-02-01), Barbas et al.
Laity et al. Current Opinion in Structural Biology. 2001;11:39-46.
Berkhout et al. AIDS Research and Human Retroviruses. Volume 18, No. 2, 2002, pp. 133-141.
Fröhlich et al. (Biology of Reproduction. 2001; 64: 1072-1079).
Choo et al. (Current Opinion in Structural Biology. 2000; 10: 411-416).
Martin et al. (Tetrahedron. 2000; 56: 9451-9460).
Russo et al (Molecular and Cellular Biology. Nov. 1993; 13(11): 6858-6865).
Beerli, et al., “Engineering polydactyl zinc-finger transcription factors”, Nature Biotechnology, Feb. 2002, vol. 20, No. 2, pp. 135-141.
Choo, et al., “Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage”, Proc. Natl. Acad. Sci. USA, Nov. 8, 1994, vol. 91, No. 23, pp. 11163-11167.
Choo, et al. “In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence”, Nature, Dec. 15, 1994, vol. 372, pp. 642-645.
Desjarlais, et al., “Length-encoded multiplex binding site determination: Application to zinc finger proteins”, Proc. Natl. Acad. Sci. USA, Nov. 1994, vol. 91, pp. 11099-11103.
Greisman, et al., “A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites”, Science, Jan. 31, 1997, vol. 275, pp. 657-661.
Jamieson, et al., “In Vitro Selection of Zinc Fingers with Altered DNA-Binding Specificity”, Biochemistry, 1994, vol. 33, pp. 5689-5695.
Kang, et al., “Zinc Finger Proteins as Designer Transcription Factors”, The Journal of Biological Chemistry, Mar. 24, 2000, vol. 275, No. 12, pp. 8742-8748.
Rebar, et al., “Zinc Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities”, Feb. 4, 1994, vol. 263, No. 5147, pp. 671-673.
Wu, et al., “Building zinc fingers by selection: Toward a therapeutic application”, Proc. Natl. Acad. Sci. USA, Jan. 1995, vol. 92, pp. 344-348.

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