Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Isomerase
Patent
1998-11-12
2000-08-29
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Isomerase
435183, 4352523, 43525233, 4353201, 536 231, 536 232, 536 237, C12N 990, C07H 2104
Patent
active
061107239
ABSTRACT:
The invention provides YfiI pseudouridine synthase polypeptides and polynucleotides encoding YfiI pseudouridine synthase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing YfiI pseudouridine synthase polypeptides to screen for antibacterial compounds.
REFERENCES:
SwissProt Submission, Accession No. P33643, Direct Submission, Feb. 1, 1994.
SwissProt Submission, Accession No. Q45480, Direct Submission, Nov. 1, 1997.
Arigoni, et al., "A Genome-based Approach for the Identification of Essential Bacterial Genes", Nature Biotechnology, vol. 16, pp. 851-856, Sep. 1998.
Kammen, et al.: "Pufification, Structure and Properties of Escherichia Coli tRNA Pseudouridine Synthetase I." Journal of Biological Chemistry, Vol. 263, No.5, pp. 2255-2263,Feb. 15,1988.
Conrad, et al.: "The rluC Gene of Eshirichia Coli Codes for a Pseudouridine Synthetase that is Solely Responsible for Synthesis of Pseudouridine at Position 955, 2504, and 2580 in 23 Ribosomal RNA." Journal of Biological Chemistry, Vol. 273, No. 29, pp. 18562-18566, Jul. 17, 1998.
Lecointe, et al.: "Characterization of Yeast Protein Deg 1 as Pseudouridine Synthetase (Pus3) Catalyzing the Formation Of .PSI.39 in tRNA Anticodon Loop." Journal of Biological Chemistry, Vol. 273. No. 3, pp. 1316-1323, Jan. 16, 1988.
Achutamurthy Ponnathapu
Deibert Thomas S.
Gimmi Edward R.
King William T.
Nashed Nashaat T.
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