Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-19
1997-08-26
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514290, 546 93, 544361, C07D40104, C07D40112, A61K 3144, A61K 31495
Patent
active
056611528
ABSTRACT:
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound containing a tricyclic ring system to a biological system. In particular, the method inhibits cellular growth in a mammal such as a human being.
Novel compounds of the formula: ##STR1## are disclosed. Also disclosed are processes for making 3-substituted compounds of Formula 4.0.
Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formula 4.0.
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Bishop W. Robert
Doll Ronald J.
Mallams Alan K.
Njoroge F. George
Petrin Joanne M.
Jeanette Henry C.
Rotman Alan L.
Schering Corporation
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