Tartrate salts of quinazoline based EGFR inhibitors...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S293000

Reexamination Certificate

active

07846938

ABSTRACT:
The present invention relates to tartrate salts of quinazoline containing zinc-binding moiety based derivatives of Formula II, below.These compounds are inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and may further act as HDAC inhibitors. The invention further relates to the use of these tartrate salts in the treatment of EGFR-TK related diseases and disorders such as cancer.

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