Synthesis of intermediates for the preparation of pramipexol

Details Synthesis of intermediates for the preparation of pramipexol Synthesis of intermediates for the preparation of pramipexol

2007-01-11

2010-02-16

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

Reexamination Certificate

active

07662610

ABSTRACT:
A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereofwherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof,wherein R1is straight or branched C1-C6alkyl, optionally substituted with phenyl; (the asterisk * and R defined above), with a lipase fromCandida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.

REFERENCES:
patent: 4731374 (1988-03-01), Griss et al.
patent: 4843086 (1989-06-01), Griss et al.
patent: 4886812 (1989-12-01), Griss et al.
patent: 4981862 (1991-01-01), Schneider et al.
patent: 4988699 (1991-01-01), Caprathe et al.
patent: 5112842 (1992-05-01), Zierenberg et al.
patent: 5650420 (1997-07-01), Hall et al.
patent: 6727367 (2004-04-01), Pospisilik
patent: 6770761 (2004-08-01), Pospisilik et al.
patent: 6982332 (2006-01-01), Dutta
patent: WO 02098367 (2002-12-01), None
patent: 2005/092871 (2005-10-01), None
patent: WO 2006/012277 (2006-02-01), None

Affiliated with

Also associated with

Rating

Synthesis of intermediates for the preparation of pramipexol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of intermediates for the preparation of pramipexol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of intermediates for the preparation of pramipexol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4208564