Radicicol derivatives, their preparation and their anti-tumor ac

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549268, A61K 31335, C07D31300

Patent

active

055978460

ABSTRACT:
A compound of the formula ##STR1## in which: R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen atoms and groups of formula R.sup.3 --CO--, wherein R.sup.3 represents a group selected from the group consisting of unsubstituted alkyl groups having from 9 to 20 carbon atoms; substituted alkyl groups having from 10 to 20 carbon atoms; unsubstituted alkenyl groups having from 9 to 20 carbon atoms; substituted alkenyl group having from 10 to 20 carbon atoms; unsubstituted alkynyl groups having from 8 to 10 carbon atoms; and substituted alkynyl groups having from 8 to 10 carbon atoms wherein R.sup.1 and R.sup.2 are not both hydrogen atoms or acetyl groups. The compounds have antitumor activity.

REFERENCES:
patent: 3428526 (1969-02-01), Sigg et al.
patent: 4166764 (1979-09-01), Calton et al.
patent: 4228079 (1980-10-01), Calton et al.
H. G. Cutler et al, "Monorden from a Novel Source, Neocosmospora tenuicristata: Stereochemistry and Plant Growth Regulatory Properties", Agri. Biol. Chem., 51, 3331-3337 (1987).
Mirrington et al, "The Constitution of Radicicol", Tetrahedron Letters, No. 7, 1964, pp. 365-370.
Chemical Abstracts, vol. 77, No. 25 (1972) No. 160508q (Betina et al).
Merck Index, Tenth Edition, 1983, pp. 894-895, Monograph No. 6107, "Monorden".
Mirrington, R. N. et al "Constitution of radicicol" CA 60:10624g (1964).
McCapra, F. et al "Constitution of monorden, an antibiotic with tranquilizing action" CA 61:14653c (1964).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Radicicol derivatives, their preparation and their anti-tumor ac does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Radicicol derivatives, their preparation and their anti-tumor ac, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radicicol derivatives, their preparation and their anti-tumor ac will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-941810

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.