Pyrimidine 2'-methylidene nucleoside compounds

Details Pyrimidine 2'-methylidene nucleoside compounds Pyrimidine 2'-methylidene nucleoside compounds

1989-12-07

1991-06-25

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, C07H 1900

Patent

active

050268350

ABSTRACT:
Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: ##STR1## wherein R.sup.1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R.sup.2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R.sup.3 and R.sup.4 represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R.sup.1 is amino or hydroxy, and both of R.sup.3 and R.sup.4 are hydrogen.
Said compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.

REFERENCES:
Takenuki et al., "Journal of Medicinal Chemistry", vol. 31, No. 6, pp. 1063-1064 (1988).
Chem. Abstr., 110, 160409h (1989).

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