Peptides having renin inhibitory activity, their preparation and

Details Peptides having renin inhibitory activity, their preparation and Peptides having renin inhibitory activity, their preparation and

1993-07-28

1995-01-03

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, A61K 3702, C07K 508

Patent

active

053786890

ABSTRACT:
Compounds of formula (I): ##STR1## [in which: R.sup.1 is heterocyclic group having 5 or 6 ring atoms, or --NR.sup.7 R.sup.8, where R.sup.7 is alkyl and R.sup.8 is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R.sup.2 is optionally substituted phenyl or naphthyl; R.sup.3 is thiazolyl; R.sup.4 is cyclohexyl or isopropyl; R.sup.5 is alkyl; and R.sup.6 is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof.

REFERENCES:
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4698329 (1987-10-01), Matsueda et al.
patent: 4727060 (1988-02-01), Buhlmayer et al.
patent: 4758584 (1988-07-01), Buhlmayer et al.
patent: 4839357 (1989-06-01), Patchett et al.

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