N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pha

Details N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pha N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pha

1976-03-29

1977-09-20

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239A, 260239BF, 260268BC, 260288R, 26029362, 2603067R, 260307R, 260307H, 260302R, 260465D, 26050114, 26032611R, 2603265SF, 260556AR, 260556B, 424250, 424258, 424262, 424267, 424270, 424272, 424274, 424285, 424309, 424316, 424321, 4242485, 544158, 560 9, C07D22304, C07D22502, A61K 31395, A61K 31445, C07D29510, C07D21108, A61K 3118, A61K 3104

Patent

active

040496457

ABSTRACT:
N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is wherein R.sub.1 and R.sub.2 are members selected from the class consisting of hydrogen, alkyl, aryl, alkenyl and cycloalkyl, respectively containing not more than 10 carbon atoms, and aralykyl and cycloalkylalkyl, respectively containing not more than 15 carbon atoms; and R' is a member selected from the class consisting of 5,6,7,8-tetrahydro-l-naphthyl, 5,6,7,8-tetrahydro-2-naphthyl, 1-naphthyl, 2-naphthyl, 1-naphthyl substituted with halogen, nitro, cyano, hydroxy, alkyl containing not more than 10 carbon atoms, and 2-naphthyl substituted with halogen, nitro, cyano, hydroxy, alkyl containing ot more than 10 carbon atoms.

REFERENCES:
patent: 3622615 (1971-11-01), Nicolaides et al.
patent: 3867447 (1975-02-01), Cherkofsky
patent: 3978045 (1976-08-01), Okamoto et al.

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