Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-12-02
1999-12-28
Houtteman, Scott W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 245, 514 44, C12Q 168
Patent
active
060079851
ABSTRACT:
Antibodies to the large subunit of DNA-dependent RNA polymerase II (Pol II LS) and methods of use thereof, including use as research tools and for the diagnosis of proliferative diseases such as cancer and the screening of anti-cancer therapies, and a method for delivering molecules to predetermined sites in the nucleus of a cell using a molecule containing the C-terminal domain of the Pol II LS protein. The anti-Pol II LS antibodies are highly specific for phosphorylated Pol II LS and bind to the C-terminal domain of the Pol II LS molecule in a phosphorylation-dependent manner.
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Houtteman Scott W.
Yale University
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