Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1993-10-06
1995-04-04
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530382, 530412, 530415, 530416, 530417, 604 5, 604 6, 436 86, 536 551, 536123, C07K 312, C07K 320, C07K 1300, A61M 134
Patent
active
054039177
ABSTRACT:
For the quantitative selective removal or/and preparative isolation of tumour necrosis factor (TNF) or/and lipopolysaccharides from aqueous liquids, in particular blood, plasma or serum, the aqueous liquid is passed over an adsorption material which consists of a porous supporting material to which functional groups made of synthetic or/and semisynthetic or/and natural polyanion chains and namely in a linear or branched form, are covalently bound and if desired, the molecules chromatographically separated in this way are eluted from the adsorption material using a saline solution. A device according to the present invention for the extracorporeal removal of tumour necrosis factor and/or lipopolysaccharides (LPS) from aqueous liquids, in particular blood, plasma or serum, consists of a cylindrical housing which is filled with an adsorption material which consists of a porous supporting material to which functional groups made of synthetic or/and semisynthetic or/and natural polyanion chains and namely in a linear or branched form, are covalently bound and is provided with covers at its front ends which each have a central inlet and outlet.
REFERENCES:
patent: 3959128 (1976-05-01), Harris
patent: 4576928 (1986-03-01), Tani
patent: 4777242 (1988-10-01), Nelles
patent: 4880915 (1989-11-01), Kajihara
patent: 4923439 (1990-05-01), Seidel et al.
patent: 4935204 (1990-06-01), Seidel et al.
patent: 5055447 (1991-10-01), Palladino et al.
patent: 5059654 (1991-10-01), Hou
patent: 5108596 (1992-04-01), Ookuma et al.
patent: 5178864 (1993-01-01), Lees et al.
patent: 5252216 (1993-10-01), Folena Wasserman et al.
Ruff et. al. "Purification & Physico-Chemical Characterization of Rabbit Tumor Meciosis Factor" J. Immunol 125(4) 1671-1677, 1980.
Abbas et al "Cellular & Molecular Immunology" 229-232 1991.
The Merck Index Tenth Ed. "Polymyxin" & Polymyxin B-Methanesulfonic Acid p. 7448 (#'s 7445 & 7446).
Abstract of Korea Patent No. 9209520 issued Oct. 17, 1992 Bae et. al.
Derwent Abstract #93-293005/37.
Boos Karl-Siegfried
Siedel Dietrich
von der Haar Friedrich
B. Braun Melsungen AG
Gromet Nancy J.
Russel Jeffrey E.
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