Indole derivatives exhibiting chymase-inhibitory activities...

Details Indole derivatives exhibiting chymase-inhibitory activities... Indole derivatives exhibiting chymase-inhibitory activities...

2005-02-08

2005-02-08

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S155000, C546S114000, C546S120000, C548S454000, C548S465000

Reexamination Certificate

active

06852734

ABSTRACT:
According to this invention, there is provided an indole derivative having the general formula (I)wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R1and R2each stand for a hydrogen atom or an alkyl group, independently, or (ii) R1and R2as taken together form a cycloalkyl group or an aromatic ring, or (iii) R1and R2as taken together form a heterocyclic ring, and R3is a hydrogen atom, a (C1-C10)alkyl group or others, R4is a substituted alkyl group and R5is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.

REFERENCES:
patent: 6432978 (2002-08-01), Tani et al.
patent: WO 9325574 (1993-12-01), None
patent: WO 0032587 (2000-06-01), None

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