Heat shock protein inducer

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

06846845

ABSTRACT:
A heat shock protein inducer is provided for purposes of preventing or treating ischemic disease or ischemia/reperfusion injury. This heat shock protein inducer has geranylgeranylacetone as an active ingredient and induces heat shock proteins in the heart.

REFERENCES:
patent: 4169157 (1979-09-01), Kijima et al.
patent: 53-145922 (1978-12-01), None
Benjamin , I.J., and McMillan, D.R., “Stress (Heat Shock) Proteins Molecular Chaperones in Cardiovascular Biology and Disease,”,Circ. Res. 83:. 117-132, Williams & Wilkens (1998).
Hutter, M.M. et al., “Heat-Shock Protein Induction in Rat Hearts: A Direct Correlation Between the Amount of Heat-Shock Protein Induced and the Degree of Myocardial Protection,”Circulation 89: 355-360; American Heart Association (1994).
Malaoyan, A. et al., “Heart acclimation increases the basal HSP72 level and alters its production dymanics during heat stress,”Am. J. Physical. 276:R1506-R1515. American Physiological Society (1999).
Maulik N. et al., “Drug-Induced Heat-Shock Preconditioning Improves Postischemic Ventricular Recovery After Cardiopulmonary Bypass,”Circulation 92(Supplement II):II-381-II3-88, American Heart Association (1995).
Mestril, R. et al., “Expression of Inducible Stress Protein 70 in Rat Heart Myogenic Cells Confers Protection against Stimulated Ischemia-induced Injury,”J. Clin. Invest. 93:759-767, American Society for Clinical Investigation (1994).
Morris, S.D. et al., “Specific Induction of the 70-kD Heat Stress Proteins by the Tyrosine Kinase Inhibitor Herbimycin-A Protects Rats Neonatal Cardiomyocytes,”J. Clin. Invest. 97:706-712, American Society for Clinical Investigation (1996).
Ooie, T. et al., “Single Oral Dose of Geranylgeranylacetone Induces Heat-Shock Protein 72 and Renders Protection Against Ischemia/Reperfusion Injury in Rat Heart,”Circulation 104:1837,1843, American Heart Association (Oct. 2001).
Saikawa T. et al., “Oral geranylgeranylacetone induces heat shock protein and produces protection against ischaemia/reperfusion injury in rat heart,”Eur. Heart J. 22:367, abstract No. 1936, W.B. Saunders (Sep. 2001).
Sun, L. et al., “Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment,”Am. J. Physiol. Heart Circ. Physiol. 278: H1091-H1097, American Physiological Society (2000).
Xu Q, et al., “Nitric Oxide Induces Heart-shock Protein 70 Expression in Vascular Smooth Muscle Cells Via Activation of Heat Shock Factor 1,”J. Clin. Invest. 100:1089-1097, American Society for Clinical Investigation (1997).
Yoshida, K. et al., “Translocation of protein kinese C-αδand ε isoforms in ischemic rat heart,”Biochem. Biophys. Acta 1317:36-44, Elesvier Publishing Company (1996).
Dialog File 351, Accession No. 2057765, Derwent WPI English language abstract for JP53-145922 (Document AL1)—no date provided.
Bradford, Marion M., “A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding,” Anal. Biochem. 72:248-254, Academic Press, Inc. 248-254 (1976).
Patent Abstracts of Japan—JP Patent Appl. Publication No. 53-145922 (Appl. Published Dec. 19, 1978); Japanese Patent Office.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heat shock protein inducer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heat shock protein inducer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heat shock protein inducer will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3380852

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.