Fusion peptides comprising an expressible bacterial gene and .be

Details Fusion peptides comprising an expressible bacterial gene and .be Fusion peptides comprising an expressible bacterial gene and .be

1982-06-10

1984-09-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 68, C07C10352, C12P 2100

Patent

active

044696310

ABSTRACT:
DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of .beta.-lipotropin and including the entire coding region for .beta.-endorphin with the exception of the C-terminal glutamine was modified, transferred to an expression transfer vector, and expressed as a fusion protein. The fusion protein was further modified in vitro to yield mature .beta.-endorphin. .beta.-endorphin was purified from a bacterial lysate. The structure and biological activity of the resulting product was proven by immunological assay, and by two independent assays designed to demonstrate biological activity.

REFERENCES:
patent: 4096237 (1978-06-01), Li
patent: 4098778 (1978-07-01), Li
patent: 4103005 (1978-07-01), Li
patent: 4105652 (1978-08-01), Meienhofer et al.
patent: 4196122 (1980-04-01), Sarantakis
patent: 4250087 (1981-02-01), Li
patent: 4350764 (1982-09-01), Baxter et al.

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