Ester of flurbiprofen and emulsion containing the same

Details Ester of flurbiprofen and emulsion containing the same Ester of flurbiprofen and emulsion containing the same

1984-06-19

1986-09-23

Friedman, Stanely J.

Drug, bio-affecting and body treating compositions

Lymphokine

514533, 514786, 514772, 514460, 514473, A61K 31235, A61K 31685

Patent

active

046135057

ABSTRACT:
There is provided a fat emulsion of an ester of flurbiprofen having the formula ##STR1## wherein R is a group of the formula ##STR2## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, R.sub.2 is a C.sub.1 -C.sub.15 alkyl group or a C.sub.2 -C.sub.8 alkenyl group, and m is zero or an integer of 1; or a lactone group of the formula ##STR3## wherein R.sub.3 and R.sub.4 are same as or different from each other and are a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and n is an integer of 1 or 2.
The emulsion containing particles of a vegetable oil dissolving the ester can be orally or parenterally administered to human or animal for analgesia, antiphlogosis and antipyresis in various diseases and exhibits a high activity with small amounts in terms of flurbiprofen as compared with flurbiprofen itself.

REFERENCES:
patent: 4280996 (1981-07-01), Okamoto et al.
patent: 4309420 (1982-01-01), Ghyczy et al.
patent: 4411894 (1983-10-01), Schrank et al.
patent: 4465693 (1984-08-01), Strauss et al.
patent: 4486417 (1984-12-01), Sugimoto et al.

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