Diazabicyclic aryl derivatives and their use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S252020, C544S238000, C544S349000, C540S556000, C540S460000, C540S472000, C548S536000, C548S470000, C546S245000, C560S180000

Reexamination Certificate

active

07662812

ABSTRACT:
This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

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Maviel, et al., Neuroscience, vol. 120, # 4, Sep. 15, 2003, pp. 1049-1059.

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