Diaminotrifluoromethylpyridine derivatives, process for their pr

Details Diaminotrifluoromethylpyridine derivatives, process for their pr Diaminotrifluoromethylpyridine derivatives, process for their pr

1994-08-03

1996-02-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142242, 5142288, 5142305, 5142372, 514247, 514248, 514249, 514252, 514258, 514259, 514300, 514301, 514302, 514307, 514312, 514314, 514318, 514336, 514337, 514338, 514339, 514340, 514341, 514342, 514343, 514352, A61K 3144, A61K 3154, A61K 31495

Patent

active

054929083

ABSTRACT:
A method of treating rheumatoid arthritis using a diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted as further defined herein.

REFERENCES:
patent: 5229403 (1993-07-01), Haga et al.
patent: 5348967 (1994-09-01), Haga et al.

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