Derivatives of p-guanidinobenzoic acid and pharmaceutical agents

Details Derivatives of p-guanidinobenzoic acid and pharmaceutical agents Derivatives of p-guanidinobenzoic acid and pharmaceutical agents

1993-06-02

1994-12-27

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142378, 514330, 514331, 514351, 514353, 514365, 514423, 514424, 514517, 514518, 514513, 514533, 514535, 558252, 558253, 558256, 560 34, A61K 31535, A61K 3144, A61K 3121, C07C32716

Patent

active

053766555

ABSTRACT:
A derivative of p-guanidinobenzoic acid of the general formula (IA): ##STR1## wherein Y represents an oxygen atom or a sulfur atom and (a) when Y is an oxygen atom, (R.sup.1).sub.m is selected from the group consisting of:

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patent: 4359046 (1982-11-01), Shaw, Jr.
patent: 4423069 (1983-12-01), Kaminski et al.
patent: 4843094 (1989-06-01), Imaki et al.
patent: 4975464 (1990-12-01), Imaki et al.
Chem. Abs., vol. 93, No. 5, Aug. 4, 1980, p. 393, No. 40319n, Columbus, Ohio; Masayuki et al.: "Inverse substrates" Part VII, Inverse substrates for trypsin-like enzymes, & J. Pharmacobio-Dyn. 1980, 3(4), 213-19.
Chemical Abstracts, vol. 94, No. 15, Apr. 13, 1981, p. 661, No. 121139b, Columbus, Ohio; & JP-A-80 100 356 (Kowa Co., Ltd.) 31 Jul. 1980.
Biochimica et Biophysica Acta, vol. 661, 1981, pp. 342-345, Elsevier/North-Holland Biomedical Press; S. Eujii et al. "New Synthetic inhibitors of Clr., Cl esterase, thrombin, plasmin, kallikrein and trypsin".
Journal of Medicinal Chemistry, vol. 29, No. 4, (Apr. 1986) pp. 514-519, American Chemical Society, Washington, D.C.; J. M. Kaminski et al.: "Synthesis and inhibition of human acrosin and trypsin . . . ".

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