Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1996-05-15
1999-09-28
Clardy, S. Mark
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544298, 544309, 544242, C07D23902
Patent
active
059591099
ABSTRACT:
Ligand inhibitors for increasing levels of free corticotropin-releasing factor (CRF) in the brain. Such ligand inhibitors cause release of CRF from the CRF/CRF-binding protein complex. Administration of the ligand inhibitors provide improvement in learning and memory, result in decreased food intake and/or provide treatment for diseases associated with low levels of CRF in the brain, notably Alzheimer's disease. The ligand inhibitor is represented by the formula: ##STR1##
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Behan Dominic P.
Erickson Philip E.
Huang Charles Q.
Liu Zhengyu
McCarthy James R.
Clardy S. Mark
Neurocrine Biosciences Inc.
Qazi Sabiha N.
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