Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-02-26
1990-04-17
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540227, 540222, C07D50124, A61K 31545
Patent
active
049180681
ABSTRACT:
There are provided new cephem compounds (synisomers) represented by the following general formula (I): ##STR1## wherein R.sup.1 means a lower group, R.sup.2 denotes an ester-forming group of the carboxyl group, and the 4-methylthiazolyl group and the cephem moiety are cis to each other relative to the carbon-carbon double bond of the substituted vinyl group in the side chain at the 3-position of the cephem nucleus. The cephem compounds exhibit strong antibacterial activities not only against resistant strains of bacteria and gram-negative bacteria but also against gram-positive bacteria and moreover have very low toxicity.
REFERENCES:
patent: 4546101 (1985-10-01), Takaya et al.
patent: 4839350 (1989-06-01), Atsumi et al.
Patent Abstracts of Japan, vol. 11, No. 200, Jun. 27, 1987, "Novel Cephem Compound".
Atsumi, et al., Chem. Abstracts vol. 106 (1987) entry 67001b.
Atsumi Kunio
Kondo Sinichi
Nishihata Ken
Sakagami Kenji
Yamamoto Yuichi
Meiji Seika Kaisha Ltd.
Rizzo Nicholas S.
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