Radiant energy – Inspection of solids or liquids by charged particles – Electron microscope type
Reexamination Certificate
2005-04-05
2005-04-05
Nguyen, Kiet T. (Department: 2881)
Radiant energy
Inspection of solids or liquids by charged particles
Electron microscope type
C250S305000
Reexamination Certificate
active
06875984
ABSTRACT:
A bio electron microscope and an observation method which can observe a bio specimen by low damage and high contrast to perform high-accuracy image analysis, and conduct high-throughput specimen preparation. 1) A specimen is observed at an accelerating voltage 1.2 to 4.2 times a critical electron accelerating voltage possible to transmit a specimen obtained under predetermined conditions. 2) An electron energy filter of small and simplified construction is provided between the specimen and an electron detector for imaging by the electron beam in a specified energy region of the electron beams transmitting the specimen. 3) Similarity between an observed image such as virus or protein in the specimen and a reference image such as known virus or protein is subjected to quantitative analysis by image processing. 4) A preparation protocol of the bio specimen is made into a chip using an MEMS technique, which is then mounted on a specimen stage part of an electron microscope to conduct specimen introduction, preparation and transfer onto a specimen holder.
REFERENCES:
patent: 5640012 (1997-06-01), Krivanek
patent: 6140645 (2000-10-01), Tsuno
patent: 6563112 (2003-05-01), Haking et al.
Hosoki Shigeyuki
Kakibayashi Hiroshi
Kobayashi Hiroyuki
Miyake Ryo
Nakamura Kuniyasu
Antonelli Terry Stout & Kraus LLP
Hitachi , Ltd.
Hitachi High-Technologies Corporation
Nguyen Kiet T.
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