Antibacterial agent and therapeutic agent for johne's...

Details Antibacterial agent and therapeutic agent for johne's... Antibacterial agent and therapeutic agent for johne's...

2009-02-11

2011-11-15

Olson, Eric S (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S016800, C536S017400

Reexamination Certificate

active

08058247

ABSTRACT:
An antibacterial agent having high antibacterial activity againstMycobacterium aviumsubsp.paratuberculosisis provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity againstMycobacterium aviumsubsp.paratuberculosisis a caprazamycin derivative represented, for example, by the following general formula (II):wherein Me is a methyl group; and R1is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.

REFERENCES:
patent: 7482439 (2009-01-01), Miyake et al.
patent: 97/41248 (1997-11-01), None
patent: 2004/067544 (2004-08-01), None
Cocito, C. et al; Paratuberculosis; Clinical Microbiology Reviews, vol. 7, No. 3, pp. 328-345, Jul. 1994.
Van Schaik, G. et al; Cost -Benefit Analysis of Vaccination Against Paratuberculosis in Dairy Cattle; Veterinary Record 139, pp. 624-627, Dec. 21/28, 1996.
Molina, J.M. et al; Study on Immune Response of Goats Vaccinated with a Live Strain ofMycobacterium paratuberculosis; Comp. Immun. Microbiol. Infect. Dis., vol. 19, No. 1, pp. 9-15, 1996.

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