Amplification of human MDM2 gene in human tumors

Details Amplification of human MDM2 gene in human tumors Amplification of human MDM2 gene in human tumors

1992-06-23

1995-05-02

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 436813, C12Q 168, C12P 1934

Patent

active

054118603

ABSTRACT:
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and appears to allow the cell to escape from p53-regulated growth.

REFERENCES:
Romkes et al. Biochemistry 30:3247-3255 (1991) "Cloning & Expression of CDNA for . . . ".
Fakharzadeh, et al., "Tumorigenic Potential Associated with Enhanced Expression of a Gene That is Amplified in a Mouse Tumor Cell Line", The EMBO Journal, 10(6):1565-1569 (1991).
Hinds, et al., "Mutant p53 DNA Clones From Human Colon Carcinomas Cooperate With Ras in Transforming Primary Rat Cells: A Comparison of the Hot Spot Mutant Phenotypes", Cell Growth & Differentiation, 1:561-580 (1990).
Oliner, et al., "Amplification of a Gene Encoding a p53-Associated Protein in Human Sarcomas, " Nature, 358:80-83 (1992).
Oliner, et al., "Oncoprotein MDM2 Conceals the Activation Domain of Tumour Suppressor p53", Nature, 362(6423):857-860 (1993), abstract.
Leach et al., "p53 Mutation and MDM2 Amplification in Human Soft Tissue Sarcomas," Cancer Research, 53:2231-2234 (1993).
Momand, et al., "The mdm-2 Oncogene Product Forms a Complex With the p53 Protein and Inhibits p53-Mediated Transactivation," Cell, 69:1237-1245 (1992).

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