Alteration of the interaction of a T-cell receptor with a protei

Details Alteration of the interaction of a T-cell receptor with a protei Alteration of the interaction of a T-cell receptor with a protei

1991-09-12

1993-10-05

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 691, 4351723, 530350, 935 70, 935 71, 935 10, C12N 500, C12N 1500, C07K 1300

Patent

active

052504310

ABSTRACT:
This invention concerns alteration of the interaction of PTKs and T-cell receptors. We have found that PTKs and T-cell receptors are complexed within the T-cell and the formation of this complex dictates the susceptibility of the T-cell to activation and to infection by viruses such as HIV. The nature of the interaction between the kinase and the T-cell receptor in a human is also related to the potential for cancer cell formation in that human, and to susceptibility to an autoimmune disease. Modified CD4 and CD8 T cell receptors and transfected mammalian cells expressing the same are disclosed.

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