Alkoxy-acyl carnitines and pharmaceutical compositions containin

Details Alkoxy-acyl carnitines and pharmaceutical compositions containin Alkoxy-acyl carnitines and pharmaceutical compositions containin

1983-08-11

1986-05-20

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560187, C07C10130, A61K 3122

Patent

active

045902097

ABSTRACT:
A novel class of alkoxy-acyl carnitines, wherein the alkoxy-acyl radical has from 4 to 6 carbon atoms (tipically: methoxypropionyl, ethoxypropionyl and propoxyacetyl) is prepared by reacting a solution of a carnitine salt in an organic solvent with an alkoxy-acyl halogenide, thus obtaining the corresponding salt of alkoxy-acyl carnitine. By eluting an aqueous solution of this salt through a column of an ion exchange resin activated in Cl.sup.- or Br.sup.- form, the chloride or bromide of alkoxy-acyl carnitine is obtained. The alkoxy-acyl carnitines are therapeutically effective in the treatment of cardiac disorders, hyperlipidaemias and hyperlipoproteinaemias.

REFERENCES:
patent: 3922340 (1975-11-01), Miwa
patent: 4032641 (1977-06-01), Chibata
patent: 4194006 (1980-03-01), Cavazza
patent: 4237167 (1980-12-01), Cavazza
Wilson, "Textbook of Organic Medical and Pharmaceutical Chemistry," pp. 39-40 (1954).
Strack, Chem. Abst. 64: 19398 (1966).
Mino, Chem. Abst. 77: 151503 (1972).

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