Actinonin derivatives and pharmaceutically acceptable salts ther

Details Actinonin derivatives and pharmaceutically acceptable salts ther Actinonin derivatives and pharmaceutically acceptable salts ther

1991-09-04

1993-04-27

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548533, 548540, C07D20708

Patent

active

052063844

ABSTRACT:
A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.

REFERENCES:
patent: 3240787 (1966-03-01), Singh et al.
patent: 4663342 (1987-05-01), Umezawa et al.
patent: 4929633 (1990-05-01), Shibahara et al.
C.A. 108(19):167973e3, Hoffmann-Laroche (1987).

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