Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1983-09-06
1986-01-21
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
260239A, 2602452T, A61K 31675, C07P 965
Patent
active
045658080
ABSTRACT:
3-Phosphonate carbapenems of the Formula: wherein R.sup.1 is hydrogen, alkyl, amino, --NHCO-alkyl, hydroxy, alkoxy, halo, hydroxyalkyl, carboxyl or trifluoromethyl; R.sup.2 is alkyl, substituted alkyl, heterocyclic or substituted heterocyclic; R.sup.3 is hydrogen, alkyl or substituted alkyl; and M is a metal cation of H.sup.+ are disclosed. The compounds are useful as antibiotics.
REFERENCES:
Mak et al., Tetrahedron Letters, vol. 24, pp. 347-350, (1983).
Andrus W. Alexander
Christensen Burton G.
Heck James V.
Berch Mark L.
Merck & Co. , Inc.
North R. J.
Pfeiffer Hesna J.
Speer R. M.
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