Preparation process of ginkgolide B from ginkgolide C

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D30777

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052410846

ABSTRACT:
The invention relates to a process for the preparation of ginkgolide B from ginkgolide C and to ginkgolide B thus obtained, the process comprising the following succession of four steps:

REFERENCES:
patent: 4734280 (1988-03-01), Braquet
patent: 5089636 (1992-02-01), Kwak et al.
Weinges, K. et al. "Isolierung und Strukturaufklarung eines neuen Ginkgolids" Liebigs Ann Chem (1987) 521-526.
J. Chem. Soc. C, 1967, vol. (21), pp. 2201-2206, see momoacetate of Ginkgolide B, p. 2205, LH column.
K. Weinges et al., "Herstellung von Ginkgolid B aus Ginkgolid C", Liebigs Annalen Der Chemie, No. 1, Jan. 1991, pp. 81-83.

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