2-aminopropane-1,3-diol compounds, medicinal use thereof,...

Details 2-aminopropane-1,3-diol compounds, medicinal use thereof,... 2-aminopropane-1,3-diol compounds, medicinal use thereof,...

2006-04-18

2006-04-18

Barts, Samuel (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S548000, C514S630000, C514S653000, C564S221000, C564S360000, C560S194000, C560S250000, C560S252000, C424S400000

Reissue Patent

active

RE039072

ABSTRACT:
The present invention relates to a compound of the general formulawherein R1, R2, R3and R4are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

REFERENCES:
patent: 3660488 (1972-05-01), Cobb
patent: 0627406 (1994-12-01), None
patent: 0 627 406 (1994-12-01), None
patent: 0778263 (1997-06-01), None
patent: 0 778 263 (1997-06-01), None
B. Vithal Shetty, et al., “Syntheses of Some 1-Alkylamino-1,1-di (hydrozymethyl)-2-phenylethanes”,J. Org. Chem., Nov. 1960, pp. 2057-2059.

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