Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-12-29
1989-11-21
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548336, 548337, A61K 31415, C07D23384
Patent
active
048823481
ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mannals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
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patent: 4600430 (1986-07-01), Abdulla et al.
P. Iversen, et al., Acta Chem. Scand. 21:279-285 (1967).
U. Gebert, et al., Chemical Abstracts 72:39275e (1970).
Kruse Lawrence I.
Ohlstein Eliot H.
Ross Stephen T.
Lourie Alan D.
McCarthy Mary E.
Schwartz Richard A.
SmithKline Beckman Corporation
Suter Stuart R.
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