16-membered macrolide derivatives and process for producing the

Details 16-membered macrolide derivatives and process for producing the 16-membered macrolide derivatives and process for producing the

1994-12-20

1996-05-21

Lilling, Herbert J.

Gas separation: processes

Solid sorption

Including reduction of pressure

95106, 95131, 95133, 95902, 96146, 96147, 206 07, B01D 53047

Patent

active

055191223

ABSTRACT:
16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms;
and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.

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H. Sakakibara et al, J. Antibiotics, 34(12), 1577 (1981).
K. Tsuzuki et al, J. Antibiotics, 39(12), 1787 (1986).

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