16-membered macrolide derivative having sustained antibacterial

Details 16-membered macrolide derivative having sustained antibacterial 16-membered macrolide derivative having sustained antibacterial

1993-02-25

1995-08-22

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 168, 549270, 549271, C07H 1708, C07D31306

Patent

active

054441749

ABSTRACT:
16-membered macrolide compounds wherein both of hydroxyl groups at the 3"- and 4"-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds represented by formula (I) are prepared by chemically modifying midecamycin A.sub.3 to obtain a synthesis intermediate of the formula (II), which is further chemically modified. ##STR1##

REFERENCES:
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T. Sato et al., Difference in Physico-Pharmaceutical Properties Between Crystalline and Monocrystalline 9,3"-diacetylmidecamycin, Chemical Pharmaceutical Bulletin, vol. 29, No. 9, 1981, pp. 2675-2682.

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