1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan

Details 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan

1988-09-30

1991-02-12

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514254, 544364, 544295, 546208, 546214, A61K 31495, A61K 31445, C07D40114

Patent

active

049924419

ABSTRACT:
Mannich bases of the formula (I): ##STR1## where X is oxygen or NR.sup.2, Alk is divalent alkyl, R.sup.1 is an aromatic ring, R.sup.2 is a substituent and the salts thereof. Useful as antipsychotic agents in man to be used in a manner similar to chlorpromazine.

REFERENCES:
patent: 4772604 (1988-09-01), Van Wijngaarden
patent: 4782061 (1988-11-01), Kruse et al.
patent: 4791132 (1988-12-01), Van Wijngaarden
2-Phenylpyrroles as Conformationally Restricted Benazmide Analogues Class of Potential Antipsychotics, 2 Wijngaarden et al., J. Med. Chem. 1988, 31,No. 10,pp. 1934-1940.
2 Phenyl Pyrroles as Conformationally Restricted Benzamide Analogues, A New Class of Potential Antipsychotics, Wijngaarden et al., J. Med. Chem. 1987, 30, 2099-2104.

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