Metal chelate forming peptides and use thereof represented by th

Details Metal chelate forming peptides and use thereof represented by th Metal chelate forming peptides and use thereof represented by th

1997-03-12

1998-07-28

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 165, 530300, 530331, 530333, A61K 5100, A61M 3614

Patent

active

057859485

ABSTRACT:
The invention provides, inter alia, metal radionuclide-labelled reagent comprising a metal radionuclide coordinated with a metal chelate forming peptide having an amino acid sequence of three amino acid residues represented by: X1-X2-Cys, wherein X1 represents an Asp residue, a Tyr residue or a Lys residue; X2 represents an amino acid residue other than a Cys residue and a Pro residue, provided that X2 does not represent a Gly residue when X1 represents an Asp residue; wherein functional groups at the N-terminus, C-terminus and side chain may be optionally substituted with protecting groups; and wherein each of the amino acid residues may be either D-form or L-form.

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6th World Congress of Nuclear Medicine and Biology, Eur. J. Nucl. Med., 21(Suppl):S46 (1994), abstract #174.
Knight et al, The Journal of Nuclear Medicine, 35(2):282-288 (1994).
Pearson et al., J. Med. Chem, vol. 39, No. 7, pp.1361-1371, "Sonatostatin Receptor Binding Peptides labeled with Technetium-99m: Chemistry and Initial Biological Studies".

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