Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1974-12-09
1976-10-12
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602472A, 2602475R, 260286R, 260286Q, 260287D, 26029387, 260471A, 260471C, 260476R, 260551R, 260569, 260571, C07D21712
Patent
active
039858812
ABSTRACT:
Novel isoquinoline derivatives of the formula ##SPC1##
Wherein R.sub.1 is H or, together with R.sub.2, a C--N bond; R.sub.2 is H, R.sub.8 or, together with R.sub.1, a C--N bond; R.sub.3 is H, methyl or ethyl; R.sub.4 and R.sub.5 each are H or collectively a C--C bond; and R.sub.6 and R.sub.7 each are H or methoxy; R.sub.8 being acyl of 1-10 carbon atoms or alkyl of 1-17 carbon atoms optionally mono- or polysubstituted by phenyl, OH, ArCOO--, ArCONH--, piperidino, 3,4-dehydropiperidino, morpholino, carboxy, carbomethoxy and/or carbethoxy, Ar being 3,4,5-trimethoxyphenyl; and the physiologically acceptable acid addition salts and quaternary ammonium salts thereof, have cardiovascular activity and can be prepared by acylating a corresponding primary amine lacking the COAr group with 3,4,5-trimethoxybenzoic acid or a functional derivative thereof.
REFERENCES:
patent: 2612503 (1952-09-01), Ullyot
patent: 2640829 (1953-06-01), Wilson et al.
patent: 3021331 (1962-02-01), Lombardino et al.
patent: 3483206 (1969-12-01), Werner
patent: 3600394 (1971-08-01), Coyne et al.
Leonard et al., "JACS," 1949, pp. 3405-3408, from CA. 45:167d.
Burger, "Medicinal Chemistry," pp. 42-497, 1966.
Becker Karl Heinz
Mehrhof Werner
Pohlke Rolf
Schliep Hans-Jochen
Merck Patent Gesellschaft mit beschrankter Haftung
Rizzo Nicholas S.
Wheeler David E.
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