Transdermal nitroglycerin pad

Details Transdermal nitroglycerin pad Transdermal nitroglycerin pad

1981-05-04

1982-06-22

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

128260, 128268, A61L 1503, A61F 1300, A61K 970

Patent

active

043362435

ABSTRACT:
The present invention provides a trans-dermal delivery pad for nitroglycerin administration, specifically a microsealed, trans-dermal nitroglycerin pad having a backing which is impervious to nitroglycerin absorption and transport and a silicon matrix affixed thereto, said silicone polymer matrix being of cross-linked silicone rubber having from about 10 to 200 micron microsealed compartments being formed by in situ cross-linking of the silicone rubber after it is mixed with a hydrophilic solvent system containing the nitroglycerin and a hydrophobic solvent which enhances nitroglycerin dispersion and transport.

REFERENCES:
patent: 3598122 (1971-08-01), Zaffaroni
patent: 3598123 (1971-08-01), Zaffaroni
patent: 3731683 (1973-05-01), Zaffaroni
patent: 3742951 (1973-07-01), Zaffaroni
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 3992518 (1976-11-01), Chien et al.
patent: 4053580 (1977-10-01), Chien et al.
patent: 4291015 (1981-09-01), Keith et al.

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