Immunoglobulins devoid of light chains

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435243, 4353201, 435326, 435348, 435363, 5303873, 536 2353, C12N 701, C12N 1563, C12P 2108, C07H 2104

Patent

active

060156953

ABSTRACT:
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.

REFERENCES:
Webster's II New Riverside University Dictionary, The Riverside Publishing Co./Houghton Mifflin Co., Boston, MA, 1995.
Hamers-Casterman et al., "Nature", 363:446-48 (1993).
Roitt et al., "Immunology", Gower Medical Publishing, London, pp. 1.5 and 5.7 (1985).
Ward et al., "Nature", 341:544-546 (1989).
Blier et al., "A Limited Number of B Cell Lineages Generates The Heterogeneity Of A Secondary Immune Response", J. Immunology, vol. 139, No. 12, pp. 3996-4006 (Dec. 15, 1987).

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