Pharmaceutical compositions for intranasal administration of dih

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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514249, A61K 914

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active

059422513

ABSTRACT:
The invention relates to pharmaceutical compositions for the intranasal administration of dihydroergotamine, apomorphine and morphine comprising one these pharmacologically active ingredients in combination with a cyclodextrin and/or a disaccharide and/or a polysaccharide and/or a sugar alcohol.

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Deutsche Apotheker Zeitung, vol. 130, No. 44, Nov. 1, 1990, pp. 2411-2415, Hermens and Merkus, Entitled "Nasale Arneimittel".
Humbert et al., Clin. Pharmacol Ther. 1996; 60:265-275, Human Pharmacokinetics of Dihydroergotamine Administered by Nasal Spray.
Abstract, in press British Journal of Clinical Pharmacology, 1998, Pharmacokinetics of Intranasal Formulations of Dihydroergotamine.
Marttin et al., Journal of Pharmaceutical Sciences, vol. 86, No. 7, Jul. 1997, Nasal Absorption of Dihydroergotamine from Liquid and Powder Formulations.
Martindale, The Extra Pharmacopoeia, 1996, p. 480.

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