Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-Co

Details Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-Co Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-Co

1997-10-14

1999-03-02

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 27, A61K 3135, A61K 3170

Patent

active

058772081

ABSTRACT:
A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG--CoA) reductase in mammals is disclosed comprising administering naringin or naringenin thereto.

REFERENCES:
Pharmacol. Ther. 67(3):433-447, 1995, "New Targets For Lipid Lowering And Atherosclerosis Prevention", C.R. Sirtori.
"Molecular Biology Of The Cell", Third Edition, Garland Publishing, Inc. Bruce Alberts et al., p. 83 (1994).
"Principles of Biochemistry", 2nd Edition, Worth Publishers, AL Lehninger, 670-673 (1993).
McGilvery, R.W., Biochemistry, pub. W.B.Saunders, p. 593, 1970.
Choi, J. Nat. Products, 54(1), pp. 218-224, Jan., Feb. 1991.

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