Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of detaching cells – digesting tissue or establishing...
Reexamination Certificate
2001-05-29
2009-06-30
Davis, Ruth A (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of detaching cells, digesting tissue or establishing...
C435S325000, C435S373000, C435S393000, C435S395000
Reexamination Certificate
active
07553664
ABSTRACT:
The present invention relates to methods for cultivating dermal fibroblasts, methods for preparing in vitro dermis equivalents, methods for preparing three-dimensional in vitro skin equivalents, an in vitro dermis equivalent, a three-dimensional in vitro skin equivalent, and methods for determining the effect of a chemical substance or of an agent on human skin cells using the in vitro dermis equivalent and/or the in vitro skin equivalent.
REFERENCES:
patent: 5946101 (1999-08-01), Kobayashi
patent: WO 95/33821 (1995-12-01), None
patent: WO 98/17791 (1998-04-01), None
patent: 197 21 661 (1998-11-01), None
patent: WO 99/00152 (1999-01-01), None
patent: WO 99/08728 (1999-02-01), None
Yang et al., “Tissue engineered artificial skin composed of dermis and epidermis”, Artificial Organs, Jan. 2000, 24(1):7-17.
O'Keefe et al., “Production of Fibronectin by Epithelium in a Skin Equivalent”, J Invest Dermatol, May 1987; 88(5):634-639.
Stark, et al., “Organotypic Keratinocyte Cocultures in Defined Medium with Regular Epidermal Morphogenesis and Differentiation.” The Journal of Investigative Dermatology; vol. 112, No. 5, May 1999, pp. 681-691.
Mio, et al., “Regulation of Fibroblast Proliferation in Three-Dimensional Collagen Gel Matrix.” In Vitro Cell. Dev. Biol.-Animal; 32:427-433, Jul./Aug. 1996.
Ulreich, et al., “Chondrocytes Maintain Their Phenotype when Cultured on a Three Dimensional Collagen Matrix”. Department of Surgery, University of Arizona Medical Center, Tucson, AZ 85724.
Schuman et al., Biomaterials, vol. 16, pp. 809-814 (1995).
Graeve Thomas
Noll Michaela
Davis Ruth A
Dickstein , Shapiro, LLP.
Fraunhofer-Gesellschaft zur Forderung der ange-wandten Forschung
LandOfFree
Three-dimensional skin model does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Three-dimensional skin model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Three-dimensional skin model will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4072485