Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1980-05-21

1982-12-21

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 22, 544 30, C07D50124

Patent

active

043650627

ABSTRACT:
New cephalosporins of the formula: ##STR1## in which n=0 or 1, R.sub.1 is a radical of the formula: ##STR2## [in which R.sub.4 is a protective radical and R.sub.5 is hydrogen, alkyl, vinyl, cyanomethyl or a protective radical], or R.sub.1 is a protective radical and R.sub.2 is a protective radical or an enzymatically removable radical, or R.sub.1 is an acyl radical which may be substituted in various ways and R.sub.2 is a protective radical, in the 3-oxoethyl-bicyclooct-2-ene or -bicyclooct-3-ene or 3-oxoethylidene-bicyclooctane form if n=0, and in the 3-oxoethyl-bicyclooct-2-ene or 3-oxoethylidene-bicyclooctane form if n=1, are useful as intermediates for the preparation of 3-thiovinyl-cephalosporins useful as antibacterial agents.

REFERENCES:
patent: 3674784 (1972-07-01), Webber
patent: 3769277 (1973-10-01), Long et al.
patent: 3823139 (1974-07-01), Underwood
patent: 4248868 (1981-02-01), Scartazzini et al.

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