Antidiabetic bicyclic compounds

Details Antidiabetic bicyclic compounds Antidiabetic bicyclic compounds

2007-05-11

2008-10-28

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S458000, C548S439000, C548S448000, C562S452000, C562S466000, C514S443000, C514S468000, C514S411000, C514S569000, C514S567000

Reexamination Certificate

active

07442808

ABSTRACT:
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

REFERENCES:
patent: 3514491 (1970-05-01), Hanessian et al.
patent: 2003/0069224 (2003-04-01), Lindstrom et al.
patent: WO 02/070516 (2002-09-01), None
patent: WO 03/020705 (2003-03-01), None
patent: WO 2004/021969 (2004-03-01), None
patent: WO 2005/066131 (2005-07-01), None

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