Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1994-04-04
1997-06-03
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
5303873, 53038822, 5303891, 530351, 536 2353, 435 7021, 4351722, 4353201, 435328, 424 851, 424 852, 424 855, C12N 520, C07K 1628, C07H 1512
Patent
active
056353880
ABSTRACT:
Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example.
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Bennett Brian D.
Broz Susan D.
Matthews William
Zeigler Francis C.
Genentech Inc.
Hutzell Paula K.
Lee Wendy M.
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