Polypeptide ESDN, polynucleotides encoding the polypeptide,...

Details Polypeptide ESDN, polynucleotides encoding the polypeptide,... Polypeptide ESDN, polynucleotides encoding the polypeptide,...

2007-05-15

2007-05-15

Tsang, Cecilia J. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C435S069100

Reexamination Certificate

active

11055679

ABSTRACT:
The invention discloses a useful and novel factor (polypeptide) which plays an important role for morbid vascular smooth muscle in restenosis after percutaneous transluminal coronany angioplasty (PTCA) and arterial sclerosis in the field of cardiovascular system.

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Kobuke et al. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. J. Biol. Chem. (Sep. 7, 2001) 276: 34105-34114.
Sequence Report. TrEMBLrel. 19, created Dec. 1, 2001. Result 1.
Manning et al. Stability of Protein Pharmaceuticals. Pharmaceutical Research (1989) 6: 903-918.
Benet et al. Pharmacokinetcs: The dynamics of Drug Absorption, Distribution, adn Elimination. McGraw-Hill (1990): 3-32.
Sequence Report, TrEMBLrel. 19, created Dec. 1, 2001. Result 1.
Benet et al. Pharmacokinetics: The dynamics of Drug Absorption, Distribution, and Elimination. McGraw-Hill (1990): 3-32.

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