Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1994-11-15
1997-04-22
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 936, 424 9364, 424 937, 514492, 514502, 514836, 436173, 1286534, 128654, A61B 5055
Patent
active
056226870
ABSTRACT:
Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone, and (ii) at least one imaging moiety linked thereto, and may be of the formula: ##STR1## wherein at least one of the R.sup.1 and R.sup.4 substituents comprises an imaging moiety, the remaining R.sup.1 and R.sup.4 substituents are spectator groups, J is an ortho-linker, and n is an integer from 4 to 8. Imaging moieties useful for CT imaging include those comprising two or more iodine atoms. Imaging moieties useful for MRI include (i) organic moieties comprising four or more fluorine atoms; (ii) nitroxyl spin labeled moieties; and (iii) metal chelate moieties.
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Krishnan Ashwin M.
Lohrmann Rolf
Hollinden Gary E.
Molecular Biosystems, Inc.
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