Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1995-09-21
1997-02-11
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
A61K 4505
Patent
active
056018150
ABSTRACT:
The invention provides in vivo methods for potentiating IL-10 mediated inhibition of cytokine production by T cells in a mammal. The method comprises co-administering to the mammal an effective amount of IL-4 and IL-10, preferably intravascularly.
REFERENCES:
patent: 5017691 (1991-05-01), Lee et al.
patent: 5132109 (1992-07-01), Dugas et al.
Ohara, et al., "Production of a Monoclonal Antibody to and Molecular Characterization of B-cell stimulatory factor," Nature, vol. 315, pp. 333-336, May, 1985.
Mosmann, et al., "Isolation of Monoclonal Antibodies for IL-4, IL-5, IL-6, and a new Th2-Specific Cytokine (IL-10), Cytokine Synthesis Inhibitory Factor, by Using a Solid Phase Radioimmunoadsorbent Assay," The Journal of Immunology, vol. 145, No. 9, pp. 2938-2945, Nov., 1990.
Meltzer, et al., "Delayed-Type Hypersensitivity and the Induction of Activated, Cytotoxic Macrophages," ed. by W. Paul, Fundamental Immunology, (2nd edition) Raven Press, N.Y., pp. 765-777, 1989.
de Waal Malefyt, et al., "Interleukin 10 (IL-10) and Viral IL-10 Strongly Reduce Antigen-specific Human T Cell Proliferation by Diminishing the Antigen-presenting Capacity of Monocytes via Downregulation of Class II Major Histocompatibility Complex Expression," Journal of Experimental Medicine, vol. 174, pp. 915-924, Oct., 1991.
de Waal Malefyt, et al., "Interleukin 10 (IL-10) Inhibits Cytokine Synthesis by Human Monocytes: An Autoregulatory Role of IL-10 Produced by Monocytes," The Journal of Experimental Medicine, vol. 174, pp. 1209-1220, Nov., 1991.
Fiorentino, et al., "Two Types of Mouse T Helper Cell IV. Th2 Clones Secrete a Factor that Inhibits Cytokine Production by Th1 Clones," J. Exp. Med., vol. 170, pp. 2081-2095, Dec., 1989.
Mosmann, et al., "Two Types of Mouse Helper T-cell Clone," Immunology Today, vol. 8, No. (s) 7 and 8, pp. 223-227, 1987.
Mosmann, et al., "TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties," Ann. Rev. Immunol., vol. 7, pp. 145-173, 1989.
Parish, R. "The Relationship Between Humoral and Cell-Mediated Immunity," Transplant. Rev., vol. 13, pp. 35-66, 1972.
Liew, F. Y. "Functional Heterogeneity of CD+ T Cells in Leishmaniasis," Immunology Today, vol. 10, No. 2, pp. 40-45, 1989.
Cher, et al., "Two Types of Murine Helper T Cell Clone. II. Delayed-Type Hypersensitivity is Mediated by T.sub.H 1 Clones," The Journal of Immunology, vol. 138, No. 11, pp. 3688-3694, Jun. 1, 1987.
Hooks, et al., "Immune Interferon in the Circulation of Patients with Autoimmune Disease," The New England Journal of Medicine, vol. 301, No. 1, pp. 5-8, Jul. 5, 1979.
Basham, et al., "Recombinant Interferon-.gamma. Increases HLA-DR Synthesis and Expression," The Journal of Immunology, vol. 130, No. 4, pp. 1492-1494, Apr., 1983.
Bottazzo, et al., "Role of Aberrant HLA-DR Expression and Antigen Presentation in Induction of Endocrine Autoimmunity," The Lancet, pp. 1115-1119, Nov. 12, 1983.
Hooks, et al., "The Role of Interferon in Immediate Hypersensitivity and Autoimmune Disease," Annals New York Academy of Sciences, pp. 21-32, 1980.
Iwatani, et al., "Thyrocyte HLA-DR Expression and Interferon-.gamma. Production in Autoimmune Thyroid Disease," Journal of Clinical Endocrinology and Metabolism, vol. 63, No. 3, pp. 695-708, 1986.
de Waal Malefyt, et al., "Interleukin-10," Current Opinion in Biology, vol. 4, pp. 314-320, 1992.
Chatelain, et al., "IL-4 Induces a Th2 Response in Leishmania major-Infected Mice," The Journal of Immunology, vol. 148, No. 4, pp. 1182-1187, Feb. 15, 1992.
Kimmenade, et al., "Expression, Renaturation and Purification of Recombinant Human Interleukin 4 from Escherichia coli, " Eur. J. Biochem., vol. 173, pp. 109-114, Feb., 1988.
Oswald, et al., "IL-10 Synergizes with IL-4 and Transforming Growth Factor-.beta. to Inhibit Macrophage Cytotoxic Activity," The Journal of Immunology, vol. 148, No. 11, pp. 3578-3582, Jun. 1, 1992.
Thompson-Snipes, et al., "Cytokine Synthesis Inhibitory Factor is a Potent Co-factor for Mast Cell Growth," Journal of Fed. Am. Soc. Exp. Biol. vol. 4, No. 7, Abstract 60, p. 1705, Jun., 1990.
Zlotnik, et al., "A Novel Cytokine Induces Proliferation of Mature and Immature Thymocytes in Combination with IL2 and IL4," Journal of Fed. Am. Soc. Exp. Biol., vol. 4,. No. 7, Abstract No. 233, p. 1734, Jun., 1990.
Fong et al., "Synthesis of Cytokines by CD8+ Mouse T Cells can be Inhibited by the Cytokine Synthesis Inhibitory Factor (CSIF) which is produced by the TH.sub.2 but not TH.sub.1 or CD8+ Cells," Journal of Fed. Am. Soc. Exp. Biol., vol. 4, No. 7, Abstract No. 279, p. 1742, Jun., 1990.
Vieira, et al., "cDNA Clones Encoding Mouse and Human Cytokine Synthesis Inhibitory Factor," Journal of Fed. Am. Soc. Exp. Biol., vol. 4, No. 7, Abstract No. 2764, p. 2172, Jun., 1990.
Fiorentino, et al., "Production of Cytokine Synthesis Inhibitory Factor (CSIF) by T Cells from Mice Infected with Schistosoma Mansoni correlates with Suppression of IFN-.gamma. Synthesis IN VIVO.," Journal of Fed. Am. Soc, Exp. Biol., Abstract No. 2870 p. 2191, Jun., 1990.
Swain et al The J. of Immunol vol. 145, No. 11 pp. 3796-3806 (1990).
Fong et al., "The Role of IFN-V in delayed-type Hyper-sensitivity . . . ", J. of Immunol., vol. 143(9), pp. 2887-2893 (1989).
Mossman et al., "Th1 and Th2 Cells . . . ," Ann. Rev. Immunol., vol. 7, pp. 145-173, (1989).
Sonillet et al., The Lancet, p. 1384, Jun. 1989.
Pene, Jerome et al., PNAS, vol. 85, pp. 6880-6884, 1988.
King et al., PNAS, vol. 86, pp. 10085-10089, 1989.
Takeuchi, T et al., "Heart Allogcrafts in Murine Systems," Transplantation, vol. 53 (6), 1281-94, Jun. 1992.
Vercelli et al., Jour. of Immunology, vol. 144(2), pp. 570-573, 1990.
Wedner, James "Basic & Clinical Immunology," Ed Shites et al., 7th Edn., Appleton & Lange, Chap 34, 1991.
Konrad, "Biological Barriers to Protein Delivery," Ed. Andus et al., Plenum Press, Chap. 14, 1993.
Osband et al., Immunology Today, vol. 11(6), pp. 193-195, 1990.
Hsu et al., International Immunology, vol. 4(5), pp. 563-569, Jan. 1992,
Mossman et al., Immunology Today, vol. 12, pp. A49-A53, 1991.
Peleman et al., J. Exp. Med., vol. 170, pp. 1751-1756, 1989.
Bello-Fernandez, et al., Immunology (1991) 72: 161-166.
Spits, et al., Int. Arch. Allergy Immunology (1992) 99: 8-15.
Howard, et al., Journal of Clinical Immunology (1992) 12(4): 239-247.
Rennick et al., Progress in Immunology vol. 8, Proceedings of the 8th International Congress of Immunology Budapest (1992) 355-360.
Fluckiger, et al., Journal of Cellular Biochemistry, Keystone Symposia on Molecular & Cellular Biology, Suppl. 16C, (1992) abst. M211, 74.
Mullin et al., Gastroenterology, 94th Annual Meeting of the Am. Gastroenterological Assoc. (1993) 10(4): A751.
Coffman Robert
Powrie Fiona
Ching, Esq. Edward P.
Sayala Chhaya D.
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